Background:

Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation.

Applications:

WB, IHC, IF

Name of antibody:

RPS6KB1 (Phospho-Ser411)

Immunogen:

Synthetic peptide of human RPS6KB1 (Phospho-Ser411)

Full name:

ribosomal protein S6 kinase, 70kDa, polypeptide 1 (Phospho-Ser411)

Synonyms：

S6K; PS6K; S6K1; STK14A; p70-S6K; p70 S6KA; p70-alpha; S6K-beta-1; p70(S6K)-alpha

SwissProt:

P23443

IHC positive control:

Human breast carcinoma

IHC Recommend dilution:

50-100

WB Predicted band size:

70 kDa; 85 kDa

WB Positive control:

MCF cells treated with EGF

WB Recommended dilution:

500-1000

IF Positive control:

MCF7 cells

IF Recommended dilution

100-200