Background:

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins.

Applications:

ELISA, IHC

Name of antibody:

OPTN

Immunogen:

Fusion protein of human OPTN

Full name:

optineurin

Synonyms：

NRP; FIP2; HIP7; HYPL; ALS12; GLC1E; TFIIIA-INTP

SwissProt:

Q96CV9

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human thyroid cancer

IHC Recommend dilution:

25-100